American Airlines — Miami (MIA) ⇄ Havana (HAV), Santa Clara (SNU), Holguín (HOG)
American is by far the largest U.S. operator to Cuba, running as many as ten Miami–Havana round trips a day at peak periods and the only remaining scheduled U.S. service to Santa Clara and Holguín. Its Miami hub is close enough to Cuba that aircraft can carry round-trip fuel from Florida, so the airline has not had to cancel routes outright over the fuel supply. Some Havana, Varadero, Holguín and Camagüey frequencies were paused during the summer of 2026 under a regulatory waiver, then restored. American passengers use a dedicated Cuba check-in area at Miami International near security checkpoints 1 and 2, and should still allow three hours before departure because online check-in is unavailable on Cuba routes.